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Beijing Journal of
Traditional Chinese Medicine

Announcement
 
Current Issue Just Accepted Archive Most Read Most Download
2018 Vol. 10, No. 3  Published: 20 June 2018
 
 
 
Last Fortress in breast surgery
2018, 10(3): 137-140  DOI:doi:10.3969/j.issn.1674-4136.2018.03.001 
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Abstract
 
On the basis of the standardized treatment,breast surgery is presenting the development tendency of pursuinga individual, minimally invasive, precise, functionprotected, paying attention to the shape and psychological rehabilitation.Minimally invasive and functional treatments have become the last fortress of breast surgery. Modified radical operation createda new epoch of clinical practice of “Breast Minimally Invasion”.Axillary lymph nodes of breast cancer has also entered the era of “Minimally Invasive and Functional Cleaning”. Mastoscopytechnology has been and is changing the traditional breast surgical method and ideain many aspects. It is a typical operation example which applies new theory and technique to solve clinical problems existing and probe physiological and the psychological rehabilitation in the treatment of the disease. It becomes the best embodiment of mammary gland “Minimally Invasive and Function”. “Minimally Invasive and Function” of breast surgery is gradually changing the face of the breast surgical therapy.A variety of humanized treatments of minimally invasion ofoperation and functional reservation of breast surgery has become the inevitable trend in the breast surgery.It practices “Addition and Subtraction”of breast surgery. This last fortress will eventually merge into community.
 
 Current status and progress of oncoplastic surgery and breast reconstruction after breast cancer
Rong Guo
2018, 10(3): 141-147  DOI:doi:10.3969/j.issn.1674-4136.2018.03.002 
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Abstract
 reast reconstruction after breast cancer have become an inevitable part of breast cancer treatment, which can improve patients quality of life without infection of prognosis.AlthoughChina has an early origin of breast reconstruction, the rapid development arises until recent years, and there is still a large gap with developed countries.Oncoplasticbreast conserving surgery and breast reconstruction after mastectomy are two major parts of breast reconstruction after breast cancer. Breast reconstruction after mastectomy including autologous reconstruction and implant reconstruction. At the same time, the rapid development of supporting technologies including lipo grafting and biological materials provide a new insight for breast reconstruction.The first comprehensive and detailed guidelinein China for breast reconstruction after breast cancer will be published this year. On the basis of the consensus, a sound training system of specialist doctors and an extensive disciplinary cooperation will promote the development of breast plastic and reconstruction in China.
 The clinical study of molecular subtyping of breast cancer and axillary lymph node metastasis
2018, 10(3): 147-149  DOI:doi:10.3969/j.issn.1674-4136.2018.03.003 
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Abstract
 ObjectiveTo analyze the relationship between molecular subtypes and axillary lymph node metastasis of breast cancer. 
MethodsThe general data,pathological results,molecular typing and metastasis of axillary lymph nodes were collected and analyzed retrospectively. 
ResultsThere were 316 cases of breast cancer in total,who had an average age of (55±13) years.The size of the tumor was (24±11)mm.According to the result of pathology, there were 81(2563%) cases of Luminal A,89(2816%) cases of Luminal B(HER2 -),56(1772%) cases of Luminal B(HER2+),51(1614%) cases of HER2 overexpression subtypes,39(1234%) cases of basallike subtypes.The proportion of axillary lymph node metastasis in Luminal A,Luminal B(HER2 -),Luminal B(HER2+), HER2 overexpression subtypes,basallike subtypes were 2593%(21/81),4494%(40/89),3571%(20/56),4510%(23/51),2051%(8/39).The positive rate of axillary lymph nodes in Luminal B(HER2 -) patients and HER2 overexpression patients was significantly higher than those in Luminal A and basallike patients(P<005). 
ConclusionsThe rate of axillary lymph node metastasis in Luminal B(HER2 -) patients and HER2 overexpression patients is higher,and these patients need careful assessment of axillary status before sentinel lymph node biopsy.
 
Retrospective analysis of clinical effects between extraperitoneal colostomy and intraperitoneal colostomy in laparoscopic Miles surgery for rectal cancer
2018, 10(3): 150-152  
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Abstract
ObjectiveTo investigate the clinical effects of extraperitoneal colostomy and intraperitoneal colostomy in laparoscopic Miles surgery for rectal cancer. 
MethodsA total of 73 rectal cancer patients who were treated with laparoscopic Miles surgery from June 2012 to June 2017 in the Affiliated Hospital of Jiangsu University were selected and divided into two groups. Thirtyfive patients in the experimental group were treated by extraperitoneal colostomy, while another 38 patients in the control group were treated by intraperitoneal colostomy. Then the intraoperative and postoperative recovery and complications of patients in the two groups were observed and compared. 
ResultsCompared with the control group, the exhaust and defecation time in the experimental group were lower (P<005), and the incidence rate of parastomal hernia in the experimental group was lower (P<005). 
ConclusionsThe clinical effect of extraperitoneal sigmoid colostomy was better than that of the intraperitoneal sigmoid colostomy in laparoscopic Miles surgery for rectal cancer, which has less complication and is worth of clinical application.
Detection and clinical significance of circulating tumor cells in periphery blood of patients with HER2 negative advanced gastric cancer
2018, 10(3): 153-155  DOI: doi:10.3969/j.issn.1674-4136.2018.03.005 
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Abstract
ObjectiveTo observe the results and explore the clinical value of circulating tumor cells (CTCs) in peripheral blood of patients with HER2 negative advanced gastric cancer. 
MethodsWe selected 35 patients with HER2 negative advanced gastric cancer confirmed by pathology from January 2016 to August 2017 in the Department of Oncology of Zhengzhou Central Hospital as the research objects, and set up 20 benign gastric disease patients as well as 20 healthy volunteers as control groups. After the sampling of 32 mL peripheral blood from subjects, the CTCs in peripheral blood were purified by negative selection using immunomagnetic technology and detected by immune fluorescence in situ hybridization (imFISH). The relationship between CTCs and the patients clinical features were analyzed. 
ResultsThe positive rate of CTCs in the gastric cancer group was 314 %(11/35), CTCs were not detected in the control groups.The positive expression of CTCs were related with the number of metastatic sites (P=0011). The positive rate of CTCs in gastric cancer patients was rarely related to gender,age,ECOG grade,pathology type(P>005). 
ConclusionsCTCs detection results,having a correlation with patients clinical features,may be used to evaluate the prognosis of patients with HER2 negative advanced gastric cancer.
 
Effect of various frequency of palonosetron on preventing chemotherapyinduced nausea and vomiting
2018, 10(3): 156-159  DOI:doi:10.3969/j.issn.1674-4136.2018.03.006 
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Abstract
ObjectiveTo evaluate the effects of various frequency of palonosetron on preventing nausea and vomiting induced by cisplatin chemotherapy. 
MethodsThe patients with malignant tumor accepted cisplatin chemotherapy from January 2015 to January 2017 were divided into the treatment group (50 cases) and the control group (50 cases). Patients in the control group were administered withpalonosetron 025 mg, 30 min before the cisplatin chemotherapy on day 1 and day 3. Patients in the treatment group were administered with palonosetron injection of 025 mg, 30 min before the treatment on days 1 to3 of chemotherapy. All thepatients were observed for one cycle of chemotherapy. Occurrence situations of vomiting, nausea, and loss of appetite werecompared. 
ResultsIn the acute phase, vomiting control efficiency in the control group showed no statistically difference compared to the treatmentgroup.In the delay phase, nausea andvomiting control efficiencywas significantly different between the control groupand the treatment group (P<005). In the delay phase, except losing of appetite, the control efficiency ofother adverse reactions showed no significant difference between the two groups. 
ConclusionsThe frequency ofpalonosetron could be appropriately increased for preventing induced nausea and vomiting induced by cisplatinchemotherapy, and the adverse reactions could be tolerant.
 
Safety evaluation of early postoperative XELOX chemotherapy in patients with colorectal cancer under the guidance of fasttrack surgery theory 
2018, 10(3): 160-163  DOI:doi:10.3969/j.issn.1674-4136.2018.03.007 
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Abstract
ObjectiveTo explore the safety and feasibility of oxaliplatin combined with capecitabine tablets(XELOX) adjuvantchemotherapy for patients with colorectal cancer(within 2 weeks after surgery)on the basis of fasttrack surgery theory during perioperative period. 
MethodsWe divided 60 cases with highrisk stage Ⅱ and stage Ⅲ radical resection of colorectal cancer into two groups,25 of them started adjuvant chemotherapy within 2 weeks after operation.The other 35 cases started adjuvant chemotherapy about 4 weeks after operation. A controlled study between the two groups was conducted. The perioperative management of the two groups was performed according to fasttrack surgery. Both groups were treated with XELOX for three weeks.The postoperative condition,complication rate,completion rate of adjuvant chemotherapy and adverse reaction of chemotherapy were observed through the two groups. 
ResultsThere was no significant difference between the two groups in basic conditionunder the basic circumstances(P>005).There were no deaths,anastomotic leakage and abdominal infection during the operation and adjuvant chemotherapy in the two groups. There were no significant differences of postoperative hospitalization, postoperative gastrointestinal recovery, and defecation time between the two groups(P>005).The adverse reactions of adjuvant chemotherapy in the early chemotherapy group and the control group were not statistically significant (P>005). 
ConclusionsBased on the application of fasttrack surgery theory, XELOX adjuvant chemotherapy is safe and feasible for early postoperative colorectal cancer.
Safety and feasibility analysis of thoracoscopic and laparoscopic assisted esophagectomy for esophageal squamous cell carcinoma
2018, 10(3): 164-167  DOI:doi:10.3969/j.issn.1674-4136.2018.03.008 
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Abstract
 ObjectiveTo investigate the safety and feasibility analysis of thoracoscopic and laparoscopic assisted esophagectomy for esophageal squamous cell carcinoma (ESCC). 
MethodsA total of 82 ESCC patients treated in our hospital from December 2013 to December 2015 were enrolled in this study. Fortytwo patients treated with thoracoscopic and laparoscopic assisted esophagectomy were enrolled as the observation group. Forty patients undergoing esophagectomy with were selected as the control group. The operation time, intraoperative blood loss, hospital stay and lymph node dissection were recorded. The complication and followup survival rates, recurrence and metastasis of the two groups were recorded in the postoperative 18month followup. 
ResultsThe operation time of the observation group was significantly louger than that of the control group, and the intraoperative blood loss, postoperative 24hour drainage, the length of hospital stay and the length of tube indwelling in the observation group were significantly lower than those in the control group (P<005); The number of lymph node dissection showed no significant difference (P>005); The number of dissected paraesophagus, subcarinal, inferior pulmonary vein node of the two group had no significant difference (P>005); The incidence rate of pulmonary infection and delayed gastric empting in the observation group were significantly lower than those in the control group, with significant difference (P<005); The incidence rates of atelectasis, pneumothorax, arrhythmia, recurrent laryngeal nerve injury, anastomotic stenosis, anastomotic fistula in two groups had no significant difference (P>005). The recurrence rate, metastasis rate, death rate and two year survival rate between the two groups had no significant difference (P>005). 
ConclusionsThe thoracoscopic and laparoscopic assisted esophagectomy has a minimally invasive advantage for esophageal squamous cell carcinoma patients, which can reduce postoperative pulmonary and gastrointestinal complications with high safety and efficacy.
Detection of EGFR gene mutations in hydrothorax of patients with NSCLC by high resolution melting
2018, 10(3): 168-170  DOI:doi:10.3969/j.issn.1674-4136.2018.03.009 
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Abstract
ObjectiveTo explore the clinical significance of detecting EGFR mutations in hydrothorax of patients with nonsmall cell lung cancer (NSCLC)by high resolution melting (HRM). 
MethodsThe mutations of EGFR in exon 1821 were detected with HRM in 30 hydrothorax samples, and compared with Sanger sequencing. 
ResultsThe total EGFR mutation rate was 2667% (8/30) detected by HRM and was 2333%(7/30) detected by Sanger sequencing. Compared with Sanger sequencing, the sensitivity of HRMwas 100%, the specificity of HRM was 9583%, the positive predict value was 8889% and the negative predict value was 100%. 
ConclusionsDetecting EGFR mutations in hydrothorax of patients with NSCLC by HRM is feasible, and suitable for promotion.
 
 Clinical efficacy and safety of bevacizumab combined with chemotherapy in treatment of advanced colorectal cancer
2018, 10(3): 171-173  DOI:doi:10.3969/j.issn.1674-4136.2018.03.010 
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Abstract
 ObjectiveTo investigate the clinical efficacy and safety of bevacizumab combined with chemotherapy in treatment of advanced colorectal cancer. 
MethodsA total of 160 patients with advanced colorectal cancer were treated in our hospital from January 2014 to January 2017. According to the order of admission, the first 80 cases were served as the control group, and the latter 80 were served as the observation group. The observation group was treated with bevacizumab combined with chemotherapy chemotherapy, the control group was treated with conventional chemotherapy. The treatment effect, tumor related mucous antigen, carcinoembryonic antigen and carbohydrate antigen 199 value of the two groups were compared. 
ResultsThe overall effective rate of the observation group was 850%, higher than that of the control group (625%), and the difference was statistically significant (P<005). The tumor related mucinous antigen, carcinoembryonic antigen and carbohydrate antigen 199 value in the observation group were lower than those in the control group, and the difference was statistically significant (P<005). The complication rate was 50% in the observation group and 63% in the control group, the difference was not statistically significant (P>005). 
ConclusionsBevacizumab combined with chemotherapy in treatment of advanced colorectal cancer can improve the shortterm clinical efficacy and reduce serum tumor markers concentration. The therapeutic regimen also has high safety.
Therapy effect analysis of strong opioid drugs in patients with cancer pain in outpatient department
2018, 10(3): 174-177  DOI:doi:10.3969/j.issn.1674-4136.2018.03.011 
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Abstract
ObjectiveTo investigate and analyze the use of strong opioid drugs in 40 patients with cancer pain, and to improve the standardization and effectiveness of the drug treatment. 
MethodsA total of 40 patients who visited our hospital for the first time during June 2017 to September 2017 were randomly selected. The criteria for selection of cases included: ① the outpatient treatment of patients with cancer pain; ② cancer pain NRS score ≥4 points (severe pain); ③ the treatment cycle≥1 month and tolerance to opioids; ④ the diagnosis was based on the pathological results, and the tumor stage was stage Ⅲ to Ⅳ, and no radical treatment was performed. According to the WHO threestep analgesic ladder principle and NCCN adult cancer pain clinical practice guideline, 40 outpatients with cancer pain were used strong opioid drugs and the dosages of drug, effects and adverse reactions were analyzed. 
ResultsA total of 40 patients were enrolled in this study. The daily dosage of morphine for pain relief was 40600 mg. The daily dosage of neuropathic pain and mixed pain was more than somatic pain and visceral pain (P<005), opioid drugs were effective in various types of cancer pain, but somatic pain treatment were the most obvious effect. The main adverse reactions were constipation (575%), nausea and vomiting (15%), dysuria (75%) and dizziness (5%). 
ConclusionsCancer pain is a kind of total pain, multimode intervention is the best treatment strategy, The effect of strong opioid drugs on the treatment of cancer visceral pain is obvious. During the process of the outpatient patients with cancer pain, grasping the titration tools and dynamic evaluation and carrying out outpatient followup work were important to embody the whole process management, improve quality of life of patients.
 
 Effect of highintensity focused ultrasound on curative effect and the level of tumor markers of advanced pancreatic cancer
2018, 10(3): 178-181  DOI:doi:10.3969/j.issn.1674-4136.2018.03.012 
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Abstract
 ObjectiveTo investigate the effect of Curative effect and the level of tumor markers on high intensityfocused ultrasound for Advanced Pancreatic Cancer. 
MethodsFrom January 2013 to July 2016, 110 patients with advanced pancreatic cancer received treatment in Peoples Hospital of Jingning. According to the methods of treatment, all patients were divided into the control group (n=55 cases) and the study group (n=55 cases). The control group was given conventional chemotherapy combined, and the study group received highintensity focused ultrasound treatment on the basis of the control group. The clinical efficacy, adverse and level of tumor markers between the two groups were compared. 
ResultsORR in the study group and the control group were 3091%and 1636% respectively, DCR were 8545% and 7272% respectively, ORR and DCR of the study group were significantly higher than those of the control group (P<005). Before treatment, the level of AFP,CA199 and CEA in two groups had no significant difference(P>005). Compared with before treatment, the levels of AFP,CA199 and CEA in the two groups were significant declined; and the levels of AFP,CA199 and CEA in study group was lower than those in control group(P<005). Nausea, vomiting and digestive tract reactions, aurigo, bone marrow depression and leukopenia or thrombocytopenia were found in both groups after treatment, but there was no significant difference between the two groups (P>005). 
ConclusionsHighintensity focused ultrasound can effectively alleviate the clinical symptoms in patients with advanced pancreatic cancer, and reduce the level of tumor markers, and have no serious adverse reactions in patients.
 
 Curative efficacy analysis of modified penile resection combined with simultaneous improvement of inguinal lymph node dissection in the treatment of penile cancer
Huang Zhicheng Huang ZhichengHuang Zhicheng
2018, 10(3): 182-183  DOI:doi:10.3969/j.issn.1674-4136.2018.03.012 
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Abstract
 ObjectiveTo analyze the clinical curative efficacy of combined penile resection and modified inguinal lymph node dissection in the treatment of penile cancer. 
MethodsA total of 9 patients who were diagnosed with advanced penile cancer in our hospital from January 2015 to August 2017 were enrolled in this study. Two patients underwent total penile resection, 7 patients underwent penile partial resection combined with simultaneous improvement of groin lymph node dissection. After the treatment, the operation, time of hospitalization and postoperative complications were analyzed. 
ResultsThe average operative time was (32778 ± 6583) min and the average intraoperative blood loss was (7111 ± 1531) mL. The average hospitalization time was (1836 ± 125) d. Postoperative complications including 1 case of skin flap necrosis need skin graft, 1 case of incision infection, 1 case of subcutaneous fluid, 1 case of lower limb lymphedema. 
ConclusionsThe treatment of penile cancer patients with penile resection or partial resection of the penis combined with simultaneous improvement of inguinal lymph node dissection can achieve better surgical results, while controlling the occurrence of postoperative complications, and improving the prognosis of a certain help.
 
 VEGF combined with tumor markers increase the diagnosis sensitivity of nonHodgkin's lymphoma
朱 丽琳
2018, 10(3): 184-186  DOI:doi:10.3969/j.issn.1674-4136.2018.03.014 
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Abstract
ObjectiveTo investigate the application of VEGF combined with tumor markers in the diagnosis and treatment of nonHodgkins lymphoma. 
MethodsFrom October 2015 to December 2017, 65 patients with nonHodgkins lymphoma(the NHL group) and 40 healthy volunteers from the Peoples Hospital of Minle County, Gansu Province, were considered as subjects. The level of VEGF, CA125, CEA and LDH were detected in all study subjects. The prognosis of patients with different degrees was analyzed. 
ResultsThe levels of VEGF and three tumor markers(LDH, CA125, CEA) in the NHL group were significantly higher than those in the healthy control group (P<005). The positive rates of three tumor markers and VEGF in the NHL group were significantly higher than those of healthy control group (P<005). The level of VEGF expression in NHL patients increased significantly, from low risk to high risk, and the level and positive rate of VEGF in high risk patients were significantly higher than those in moderate and low risk patients (P<005). The sensitivity and negative predictive value of VEGF combined with tumor markers to NHL were significantly higher than that of tumor markers (P<005). But there was no significant difference in specificity and positive predictive value between VEGF combined with tumor markers and tumor markers (P>005). 
ConclusionsDetection of VEGF combined with tumor markers can improve the sensitivity of NHL diagnosis, and is closely related to the malignancy of NHL.
 Diagnosis of benign and malignant renal tumors by acoustic radiation force impulse imaging and contrastenhanced ultrasonography
2018, 10(3): 187-189  DOI:doi:10.3969/j.issn.1674-4136.2018.03.014 
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Abstract
 ObjectiveTo investigate the diagnosis of benign and malignant renal tumors by Ultrasound Power Pulsed Imaging and Ultrasonography. 
MethodsFrom June 2015 to August 2017, 68 renal tumor patients were treated in Traditional Chinese Medicine Hospital of Heshui County and Qingyang Peoples Hospital considered as research objects. All of patients were examined by acoustic radiation force impulse(ARFI) imaging and contrastenhanced ultrasound,and the results of postoperative pathological examination were the gold standard. The sensitivity, accuracy, specificity, positive predictive value and negative predictive value of ultrasound power pulse imaging and contrastenhanced ultrasonography in the diagnosis of benign and malignant renal tumors were compared. 
ResultsAmong 68 cases of renal tumors, 51 cases were malignant. 41 cases were renal clear cell, 5 cases were papillary carcinoma, 3 cases chromophobe cell carcinoma and 2 cases of unclassified renal cell carcinoma. Seventeen cases were benign angiomyolipoma. 14 cases of angiomyolipoma and 3 cases of eosinophilic adenoma. According to the results of ARFI, 47 cases were diagnosed as malignant lesions and 21 cases benign lesions. Contrastenhanced ultrasonography showed that 43 cases were characterized as malignant lesions, while 25 cases showed concentric enhancement pattern as benign lesions. There was no significant difference in sensitivity, accuracy and specificity between ARFI and contrastenhanced ultrasonography in the qualitative diagnosis of renal tumors (P>005). However, the combined diagnosis of ARFI and contrastenhanced ultrasonography improved the sensitivity and accuracy in the diagnosis of benign and malignant renal tumors. 
ConclusionsARFI and contrastenhanced ultrasound have important value in the qualitative diagnosis of renal tumors. ARFI combined with contrastenhanced ultrasound can improve the sensitivity and accuracy and are beneficial to the diagnosis and treatment of renal neoplasms, but there is still a need for a large sample to be confirmed in clinical trials.
Diagnosis and surgical treatment of appendiceal mucinous tumor
2018, 10(3): 190-192  DOI:doi:10.3969/j.issn.1674-4136.2018.03.016 
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Abstract
ObjectiveTo explore the diagnosis and surgical treatment of the appendiceal mucinous tumor. 
MethodsThe clinical data of 24 patients with appendiceal mucinous tumor, whom treated in the Fourth Affiliated Hospital of China Medical University from 2007 to 2017 were retrospectively analyzed. 
ResultsAppendicitis and abdominal mass were the major clinical manifestations of appendiceal mucinous tumor. All 24 patients received surgical operation and confirmed by the histopathological diagnosis. There were 2 cases for mucinous cystadenoma of the appendix, 12 cases for lowgrade appendiceal mucinous tumor, 10 cases for appendiceal mucinous cystadenocarcinoma. All of them were treated with surgical resection,including single appendectomy in 5 cases, right hemicolectomy in 15 cases, resection of appendix and ileocecum in 4 cases. Two cases died in 2 and 3 years after operation, 3 cases with adenocarcinoma died of other diseases, and 1 case with adenocarcinoma was operated,bacause of tumor recurrence at one year after operation. No recurrence or metastasis has been found in the other patients after. 
ConclusionsAppendiceal mucinous tumor which lack specific clinical features are uncommon and difficult to be diagnosed. However, combined with domestic and foreign literatures and clinical data, we found that CT has a high clinical value in the diagnosis of appendiceal mucinous tumors. Operation is the main treatment of appendiceal mucinous tumors, and operation choice is particularly important. The main surgical methods were appendectomy, right hemicolectomy and resection of ileocecum.
 
Research progress of small interfering RNA suppressing the effect of dendritic cell vaccine IL10 receptor on esophageal cancer cells
Xiao-Lei zhuzhu Zhu zijiang
2018, 10(3): 193-197  DOI:doi:10.3969/j.issn.1674-4136.2018.03.017 
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Abstract
Esophageal cancer is one of the most common fatal malignant tumors in our country. The effect of traditional surgery, radiotherapy and chemotherapy is still unsatisfactory. DC tumor vaccine is currently one of the most promising treatment, however, the traditional tumor vaccine effect is poor, and the reason may be related to its differentiation inhibition. Among them, IL10 is one of the most potent inhibitors of immunosuppression, and almost all of DCs and monocytes are targets of IL10 inhibitory activity. Through inhibition of IL10 receptor expression in dendritic cells by siRNA technology, dendritic cells lacking IL10 receptor are cultured. Dendritic cells loaded with esophageal cancer cell antigen are prepared, thereby to prepare a dendritic high efficiency tumor vaccine loaded with esophageal cancer cells and improve the therapeutic effect of the DC vaccine on tumor as well as to provide a new idea for combining tumor immunotherapy with tumor gene therapy in esophageal cancer.
 
Sclerosing epithelioid fibrosarcoma of the intraoral buccal region: a case report
dawei daweidawei
2018, 10(3): 200-201  DOI:doi:10.3969/j.issn.1674-4136.2018.03.019 
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Abstract
 
2018, 10(3): 202-204  DOI:doi:10.3969/j.issn.1674-4136.2018.03.020 
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Abstract
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